Ki Summary

Reaction Details

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Target

Cysteine protease ATG4B

Ligand

BDBM79255

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.

IC50

6430±n/a nM

Citation

PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Cysteine protease ATG4B

Name:

Cysteine protease ATG4B

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44279.79

Organism:

Homo sapiens (Human)

Description:

gi_47132611

Residue:

393

Sequence:

MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL

BDBM79255

n/a

Name

BDBM79255

Synonyms:

MLS002153690 | RI-GK | SMR001231068 | cid_25162995

Type

Small organic molecule

Emp. Form.

C64H112N20O7

Mol. Mass.

1273.7039

SMILES

[#6]-[#6]-[#6@H](-[#6])-[#6@@H](-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-c1nc(-[#7]-[#6]-[#6]-[#8]-[#6]-[#6]-[#8]-[#6]-[#6]-[#8]-[#6]C#C)nc(n1)-[#7]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-n1cc(-[#6])nn1)-n1cc(-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])nn1

Structure