Ki Summary

Reaction Details

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Target

Hexokinase HKDC1 [W721R]

Ligand

BDBM76184

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay

IC50

12400±n/a nM

Citation

PubChem, PC Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Hexokinase HKDC1 [W721R]

Name:

Hexokinase HKDC1 [W721R]

Synonyms:

HKDC1 | HKDC1_HUMAN | putative hexokinase HKDC1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

102520.24

Organism:

Homo sapiens (Human)

Description:

gi_156151420

Residue:

917

Sequence:

MFAVHLMAFYFSKLKEDQIKKVDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAA
VKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVAEEGKRHVQMESQFYPTPNEIIR
GNGTELFEYVADCLADFMKTKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGV
QDTDVVSRLTKAMRRHKDMDVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYME
DMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGL
YLGELVRLILLKMAKAGLLFGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLG
LEPSEADCIAVQHVCTIVSFRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIH
PQYPKRLHKVVRKLVPSCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDRVLALFQLT
REQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLPDGTEKGKFLALDLGGTNFRV
LLVKIRSGRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGASLPLGFT
FSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAVVNDTVGT
MMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEGGEGKMCINTEWGGFGDNGCIDDI
RTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQILIDLTKQGLLFRGQISERLRTRGI
FETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQLCGAGLAAI
VEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQETVKELAPRCDVTFMLSEDGSGKGA
ALITAVAKRLQQAQKEN

BDBM76184

n/a

Name

BDBM76184

Synonyms:

4-[(2,9-dioxo-1,2,4,5,6,7,8,9-octahydropyrazolo[5,1-b]quinazolin-3-yl)diazenyl]benzenesulfonamide | 4-[2-(2,9-dioxo-5,6,7,8-tetrahydro-1H-pyrazolo[5,1-b]quinazolin-3-ylidene)hydrazinyl]benzenesulfonamide | 4-[2-[2,9-bis(oxidanylidene)-5,6,7,8-tetrahydro-1H-pyrazolo[5,1-b]quinazolin-3-ylidene]hydrazinyl]benzenesulfonamide | 4-[N'-(2,9-diketo-5,6,7,8-tetrahydro-1H-pyrazolo[5,1-b]quinazolin-3-ylidene)hydrazino]benzenesulfonamide | MLS000705743 | SMR000231775 | cid_16189729

Type

Small organic molecule

Emp. Form.

C16H16N6O4S

Mol. Mass.

388.401

SMILES

NS(=O)(=O)c1ccc(cc1)N=Nc1c2[nH]c3CCCCc3c(=O)n2[nH]c1=O |w:11.12|

Structure