| Reaction Details |
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 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
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| Ligand | BDBM50117198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Inhibition Assay |
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| IC50 | 0.23±0.12 nM |
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| Citation |  Fleischer, TC; Murphy, BR; Flick, JS; Terry-Lorenzo, RT; Gao, ZH; Davis, T; McKinnon, R; Ostanin, K; Willardsen, JA; Boniface, JJ Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol17:659-64 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nicotinamide phosphoribosyltransferase |
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| Name: | Nicotinamide phosphoribosyltransferase |
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| Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55524.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43490 |
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| Residue: | 491 |
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| Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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| BDBM50117198 |
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| n/a |
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| Name | BDBM50117198 |
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| Synonyms: | 4-{[7-Chloro-3-methyl-2-(4-methyl-piperazin-1-ylmethyl)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-N-pyridin-3-ylmethyl-benzamide | CHEMBL123756 | MPI-0479626 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H34ClN7O2 |
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| Mol. Mass. | 584.111 |
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| SMILES | CN1CCN(Cc2nc3cc(Cl)c(CN(CC#C)c4ccc(cc4)C(=O)NCc4cccnc4)cc3c(=O)n2C)CC1 |
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| Structure | 
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