| Reaction Details |
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 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
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| Ligand | BDBM81423 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 8±0 |
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| Temperature | 298.15±0 K |
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| IC50 | 7.0e+4±n/a nM |
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| Citation |  Gollapalli, DR; Macpherson, IS; Liechti, G; Gorla, SK; Goldberg, JB; Hedstrom, L Structural determinants of inhibitor selectivity in prokaryotic IMP dehydrogenases. Chem Biol17:1084-91 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Inosine-5'-monophosphate dehydrogenase |
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| Name: | Inosine-5'-monophosphate dehydrogenase |
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| Synonyms: | IMDH_STRPY | Inosine-5-monophosphate dehydrogenase (IMPDH) | guaB | impD |
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| Type: | Protein |
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| Mol. Mass.: | 52801.05 |
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| Organism: | Streptococcus pyogenes |
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| Description: | P0C0H6 |
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| Residue: | 493 |
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| Sequence: | MSNWDTKFLKKGYTFDDVLLIPAESHVLPNEVDLKTKLADNLTLNIPIITAAMDTVTGSK
MAIAIARAGGLGVIHKNMSITEQAEEVRKVKRSENGVIIDPFFLTPEHKVSEAEELMQRY
RISGVPIVETLANRKLVGIITNRDMRFISDYNAPISEHMTSEHLVTAAVGTDLETAERIL
HEHRIEKLPLVDNSGRLSGLITIKDIEKVIEFPHAAKDEFGRLLVAAAVGVTSDTFERAE
ALFEAGADAIVIDTAHGHSAGVLRKIAEIRAHFPNRTLIAGNIATAEGARALYDAGVDVV
KVGIGPGSICTTRVVAGVGVPQVTAIYDAAAVAREYGKTIIADGGIKYSGDIVKALAAGG
NAVMLGSMFAGTDEAPGETEIYQGRKFKTYRGMGSIAAMKKGSSDRYFQGSVNEANKLVP
EGIEGRVAYKGAASDIVFQMLGGIRSGMGYVGAGDIQELHENAQFVEMSGAGLIESHPHD
VQITNEAPNYSVH
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| BDBM81423 |
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| n/a |
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| Name | BDBM81423 |
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| Synonyms: | N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-1,3-benzodiazol-1-yl]acetamide, Compound C |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N4O2S |
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| Mol. Mass. | 364.421 |
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| SMILES | COc1ccc(NC(=O)Cn2c(nc3ccccc23)-c2cscn2)cc1 |
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| Structure | 
|
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