Reaction Details |
| Report a problem with these data |
Target | Cyclin-dependent kinase 2 |
---|
Ligand | BDBM8061 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | In Vitro Kinase Assay |
---|
Ki | <1±0 nM |
---|
Citation | Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol17:1111-21 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cyclin-dependent kinase 2 |
---|
Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
|
|
|
BDBM8061 |
---|
n/a |
---|
Name | BDBM8061 |
Synonyms: | 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4 | 4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine | CDK Inhibitor, 1 | [4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine |
Type | Small organic molecule |
Emp. Form. | C14H12N6O2S |
Mol. Mass. | 328.349 |
SMILES | Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1 |
Structure |
|