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TargetCDK7/Cyclin H/MNAT1
LigandBDBM81432
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Assay
Ki 127±48 nM
Citation Wang SGriffiths GMidgley CABarnett ALCooper MGrabarek JIngram LJackson WKontopidis GMcClue SJMcInnes CMcLachlan JMeades CMezna MStuart IThomas MPZheleva DILane DPJackson RCGlover DMBlake DGFischer PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol 17:1111-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
CDK7/Cyclin H/MNAT1
Name:CDK7/Cyclin H/MNAT1
Synonyms:39 kDa protein kinase | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 | Cyclin-dependent kinase 7 (CDK7/cyclin H) | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:Enzyme Subunit
Mol. Mass.:39047.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81432
n/a
NameBDBM81432
Synonyms:CDK Inhibitor, 5
TypeSmall organic molecule
Emp. Form.C15H16N6O2S2
Mol. Mass.376.457
SMILESCNS(=O)(=O)c1cccc(Nc2nccc(n2)-c2sc(N)nc2C)c1
Structure
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