| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H1 receptor |
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| Ligand | BDBM81467 |
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| Substrate/Competitor | n/a |
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| Ki | 250±n/a nM |
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| Comments | PDSP_1188 |
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| Citation |  Tran, VT; Chang, RS; Snyder, SH Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramine. Proc Natl Acad Sci U S A75:6290-4 (1978) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Histamine H1 receptor |
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| Name: | Histamine H1 receptor |
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| Synonyms: | HISTAMINE H1 | HRH1_RAT | Hrh1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55716.35 |
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| Organism: | RAT |
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| Description: | HISTAMINE H1 HRH1 RAT::P31390 |
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| Residue: | 486 |
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| Sequence: | MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC
ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR
SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF
RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT
DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM
AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK
ILHIRS
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| BDBM81467 |
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| n/a |
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| Name | BDBM81467 |
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| Synonyms: | CAS_569-65-3 | CHEMBL1085765 | Meclizine | NSC_4034 | US9182402, 13 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClN2 |
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| Mol. Mass. | 390.948 |
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| SMILES | Cc1cccc(CN2CCN(CC2)C(c2ccccc2)c2ccc(Cl)cc2)c1 |
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| Structure | 
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