Reaction Details |
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Target | Bis(5'-adenosyl)-triphosphatase |
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Ligand | BDBM81592 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzyme Inhibition Assay |
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Ki | 420±0.0 nM |
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Citation | Varnum, JM; Baraniak, J; Kaczmarek, R; Stec, WJ; Brenner, C Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement. BMC Chem Biol1:3 (2001) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bis(5'-adenosyl)-triphosphatase |
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Name: | Bis(5'-adenosyl)-triphosphatase |
Synonyms: | AP3A hydrolase | AP3Aase | Bis(5'adenosyl)-triphosphatase | Dinucleosidetriphosphatase | FHIT | FHIT_HUMAN | Fragile histidine triad protein |
Type: | Protein |
Mol. Mass.: | 16861.00 |
Organism: | Homo sapiens (Human) |
Description: | P49789 |
Residue: | 147 |
Sequence: | MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFHDLRPDEVADLFQ
TTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKH
DKEDFPASWRSEEEMAAEAAALRVYFQ
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BDBM81592 |
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n/a |
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Name | BDBM81592 |
Synonyms: | AppppA analog, 17 (X=O) |
Type | Small organic molecule |
Emp. Form. | C23H29N10O18P3 |
Mol. Mass. | 826.456 |
SMILES | Nc1ncnc2n(cnc12)C1O[C@H](COP([O-])(=O)OCC(COP([O-])(=O)OCC2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)OP([O-])([O-])=O)[C@@H](O)[C@H]1O |r| |
Structure |
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