| Reaction Details |
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 | Report a problem with these data |
| Target | Tubulin alpha chain |
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| Ligand | BDBM81748 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Activity Assay |
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| IC50 | 5.8e+4± 7e+3 nM |
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| Citation |  Morgan, RE; Ahn, S; Nzimiro, S; Fotie, J; Phelps, MA; Cotrill, J; Yakovich, AJ; Sackett, DL; Dalton, JT; Werbovetz, KA Inhibitors of tubulin assembly identified through screening a compound library. Chem Biol Drug Des72:513-24 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tubulin alpha chain |
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| Name: | Tubulin alpha chain |
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| Synonyms: | Alpha-tubulin | Tubulin |
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| Type: | Protein |
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| Mol. Mass.: | 49756.63 |
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| Organism: | Leishmania tarentolae (Sauroleishmania tarentolae) |
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| Description: | Q1A5Y2 |
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| Residue: | 451 |
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| Sequence: | MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGSMPSDKCIGVEDDAFNTFFSETGAGK
HVPRCLFLDLEPTVVDEVRTGTYRQLFNPEQLVSGKEDAANNYARGHYTIGKEIVDLALD
RIRKLADNCTGLQGFMVFHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTA
VVEPYNCVLSTHSLLEHTDVATMLDNEAIYDLTRRSLDIERPSYTNVNRLIGQVVSSLTA
SLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVVSAEKAYHEQLSVSDITNSVFEPAG
MLTKCDPRHGKYMSCCLMYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKCGINYQPP
TVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGAESADDMGEEDVEEY
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| BDBM81748 |
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| n/a |
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| Name | BDBM81748 |
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| Synonyms: | Chembridge No 7946770, Class 1, 9 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N2O4S |
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| Mol. Mass. | 374.454 |
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| SMILES | CCOc1cccc(c1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 |
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| Structure | 
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