Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50136166 |
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Substrate/Competitor | n/a |
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Ki | 1659.58±n/a nM |
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Comments | PDSP_832 |
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Citation | Wong, DT; Threlkeld, PG; Robertson, DW Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. Neuropsychopharmacology5:43-7 (1991) [PubMed] |
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More Info.: | Get all data from this article |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50136166 |
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n/a |
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Name | BDBM50136166 |
Synonyms: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine | (R)-fluoxetine | CHEMBL153036 | FLUOXETINE | Methyl-[(R)-3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine | Methyl-[3-phenyl-3-(4-trifluoromethyl-phenoxy)-propyl]-amine |
Type | Small organic molecule |
Emp. Form. | C17H18F3NO |
Mol. Mass. | 309.3261 |
SMILES | CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1 |r| |
Structure |
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