Reaction Details |
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Target | Beta-arrestin-2 |
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Ligand | BDBM50014247 |
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Substrate/Competitor | n/a |
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Ki | 1905.46±n/a nM |
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Comments | PDSP_811 |
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Citation | Wong, DT; Threlkeld, PG; Robertson, DW Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. Neuropsychopharmacology5:43-7 (1991) [PubMed] |
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More Info.: | Get all data from this article |
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Beta-arrestin-2 |
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Name: | Beta-arrestin-2 |
Synonyms: | 5-HT2C | ARRB2 | ARRB2_BOVIN | Beta-arrestin-2 | HTR2C |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 47232.00 |
Organism: | Beef |
Description: | 5-HT2C HTR2C Beef::P32120 |
Residue: | 420 |
Sequence: | MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTC
AFRYGREDLDVLGLSFRKDLFIANYQAFPPTPNPPRPPTRLQERLLRKLGQHAHPFFFTI
PQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPG
PQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYA
DICLFSTAQYKCPVAQVEQDDQVSPSSTFCKVYTITPLLSNNREKRGLALDGKLKHEDTN
LASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIALPRPQS
AATHPPTLLPSAVPETDAPVDTNLIEFETNYATDDDIVFEDFARLRLKGLKDEDYDDQFC
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BDBM50014247 |
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n/a |
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Name | BDBM50014247 |
Synonyms: | (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine | 3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) | CHEMBL94739 | Femoxetine |
Type | Small organic molecule |
Emp. Form. | C20H25NO2 |
Mol. Mass. | 311.418 |
SMILES | COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 |
Structure |
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