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TargetcGMP-dependent protein kinase 1
LigandBDBM3033
Substrate/CompetitorHistone II-A
Meas. Tech.cGPK assay
IC50 6200±n/a nM
Citation Kleinschroth, J; Hartenstein, J; Rudolph, C; Schachtele, C Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties. Bioorg Med Chem Lett5:55-60 (1995)    Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cGMP-dependent protein kinase 1
Name:cGMP-dependent protein kinase 1
Synonyms:CGK 1 alpha | KGP1_BOVIN | PRKG1 | PRKG1B | PRKGR1A | PRKGR1B | cGMP-Dependent Protein Kinase | cGMP-dependent protein kinase 1 alpha | cGMP-dependent protein kinase 1, alpha isozyme
Type:Enzyme
Mol. Mass.:76413.14
Organism:Bos taurus (bovine)
Description:n/a
Residue:671
Sequence:
MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQSVLPVPSTHIGPRTTR
AQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDNDFMKNLELSQIQEIVDCMY
PVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILYNCTRTAT
VKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVPTFQSLPEEILSKLADVLEET
HYENGEYIIRQGARGDTFFIISKGKVNVTREDSPNEDPVFLRTLGKGDWFGEKALQGEDV
RTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNKAYEDAEAKAKYEAEAAFFANLKLSDF
NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF
IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI
IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD
YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS
ERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEPP
PDDNSGWDIDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM3033
Histone II-A
Name:Histone II-A
Synonyms:n/a
Type:Other Protein Type
Mol. Mass.:358.43
Organism:n/a
Description:Unfractionated whole histone. 10 uM ATP (0.3 uCi [gamma-32P]ATP) as co-substrate.
Residue:3
Sequence:
n/a