| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM82480 |
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| Substrate/Competitor | n/a |
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| Ki | 140±n/a nM |
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| Comments | PDSP_2200 |
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| Citation |  Nishida, A; Miyata, K; Tsutsumi, R; Yuki, H; Akuzawa, S; Kobayashi, A; Kamato, T; Ito, H; Yamano, M; Katuyama, Y Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther269:725-31 (1994) [PubMed] |
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| More Info.: | Get all data from this article |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | Cckbr | Cholecystokinin A | Cholecystokinin B receptor | Cholecystokinin receptor | GASR_RAT | Gastrin/cholecystokinin type B receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48980.43 |
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| Organism: | RAT |
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| Description: | Cholecystokinin A CCKBR RAT::P30553 |
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| Residue: | 452 |
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| Sequence: | MELLKLNRSVQGPGPGSGSSLCRPGVSLLNSSSAGNLSCDPPRIRGTGTRELEMAIRITL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAISYLMGVSVSVSTLNLVAIALERYSAICRPLQARVWQTRSHAARVILATWL
LSGLLMVPYPVYTMVQPVGPRVLQCMHRWPSARVQQTWSVLLLLLLFFIPGVVIAVAYGL
ISRELYLGLHFDGENDSETQSRARNQGGLPGGAAPGPVHQNGGCRPVTSVAGEDSDGCCV
QLPRSRLEMTTLTTPTPGPVPGPRPNQAKLLAKKRVVRMLLVIVLLFFLCWLPVYSVNTW
RAFDGPGAQRALSGAPISFIHLLSYVSACVNPLVYCFMHRRFRQACLDTCARCCPRPPRA
RPQPLPDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM82480 |
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| n/a |
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| Name | BDBM82480 |
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| Synonyms: | YM022 S-isomer |
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| Type | n/a |
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| Emp. Form. | C32H28N4O3 |
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| Mol. Mass. | 516.5897 |
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| SMILES | Cc1cccc(NC(=O)N[C@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 |r,t:11| |
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| Structure | 
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