Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50056101 |
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Substrate/Competitor | n/a |
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Ki | >10000±n/a nM |
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Comments | PDSP_2202 |
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Citation | Nishida, A; Miyata, K; Tsutsumi, R; Yuki, H; Akuzawa, S; Kobayashi, A; Kamato, T; Ito, H; Yamano, M; Katuyama, Y Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo. J Pharmacol Exp Ther269:725-31 (1994) [PubMed] |
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More Info.: | Get all data from this article |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | HISTAMINE H1 | HRH1 | HRH1_CAVPO |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55641.53 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | Guinea pig cerebellum was used in binding assay. |
Residue: | 488 |
Sequence: | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYA
VRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVAS
TASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAP
TSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSL
PSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSE
DEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFP
ITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGC
IMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTF
KRILRIPP
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BDBM50056101 |
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n/a |
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Name | BDBM50056101 |
Synonyms: | 1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-m-tolyl-urea | CHEMBL115121 | YM022 | YM022 Racemate |
Type | Small organic molecule |
Emp. Form. | C32H28N4O3 |
Mol. Mass. | 516.5897 |
SMILES | Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 |t:11| |
Structure |
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