| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2C |
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| Ligand | BDBM21397 |
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| Substrate/Competitor | n/a |
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| Ki | 977.23±n/a nM |
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| Comments | PDSP_1739 |
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| Citation |  Millan, MJ; Canton, H; Gobert, A; Lejeune, F; Rivet, JM; Bervoets, K; Brocco, M; Widdowson, P; Mennini, T; Audinot, V Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther268:337-52 (1994) [PubMed] |
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| More Info.: | Get all data from this article |
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| 5-hydroxytryptamine receptor 2C |
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| Name: | 5-hydroxytryptamine receptor 2C |
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| Synonyms: | 5-HT2C | HTR2C |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51519.58 |
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| Organism: | PIG |
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| Description: | G7ZKZ7 |
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| Residue: | 457 |
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| Sequence: | MVNLRKAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSI
VIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVW
PLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAVRGPVEHSRFNSRTKAIMKIAIVWA
ISLGVSVPIPVIGLRDEDKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHV
LRRQALMLLRGHTEEPPGISLDFLKCCKRNTDEESAANPNQDLNPRRRKKKERRPRGTMQ
AINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCS
GINPLVYTLFNKVYRRAFSNYLRCNYKADKKPPIRQIPRVAATALSGRELNVNIYRHTNE
PVIKKADDNEPGIEMQVENLELPVNPSNVVSERISSV
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| BDBM21397 |
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| n/a |
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| Name | BDBM21397 |
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| Synonyms: | 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | CHEMBL267930 | MLS000028615 | SMR000058674 | SPIPERONE | Spiroperidol | US9359372, Spiperone | [3H]-Spiroperidol | cid_5265 |
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| Type | radiolabeled ligand |
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| Emp. Form. | C23H26FN3O2 |
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| Mol. Mass. | 395.4698 |
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| SMILES | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 |
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| Structure | 
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