| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Ligand | BDBM34408 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase |
|---|
| IC50 | 70600±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Name: | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 109731.64 |
|---|
| Organism: | Plasmodium falciparum 3D7 |
|---|
| Description: | gi_12381848 |
|---|
| Residue: | 950 |
|---|
| Sequence: | MEYETSLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSG
GKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQ
LYKPDTKKDLVSCIRDYNEQIKSMIEKYKKIDIVILGMGSDFHIASLFPNVYYNIYMNNY
QNNYIYEDNETIRSLNADNNVNLSLLNEQVYFTTTNNFDVRKRITVSLNLLSNSTSKIFL
LNTADKLNLWKNMLLNFYVNPNYNLYPAFKMIDSSNTTVIACGHKNYSKMLEDLYVQKDE
ALSPISNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTGQ
DFESFFNKIAIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSPESFENFDVYIT
QEERIALGCCGQKGNEKHKQVNVTSQFPNNHTSINIINNIDNGCESPMLTDSPKRYPCSS
SYSSTSGTAVCPYSSQHDVKPSNNGCPYLSSQANTSDSSGCPYISYHTNKSGHLGCPYTI
TRMLYLALPPHVFVSTLQNYKKYCLNKNRINKILLEKPFGKDLESFKILSKQILETFPEK
NIYRIDHYLGKDMVSGLLKLKFTNIFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYG
IIRDVMQNHMLQLLALITMEHPTDLNDKSIQNEKIKILKSIASIKLEDTVIGQYVKSNND
DTNNNINSNISENASIDKSKINHSYHDDPHVDPNSITPTFCACVLYINSINWHGVPIILK
AGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQ
LNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHIKP
LSYPFGSSGPQEAYDLVRKYYNYGKNYATTAKFCRKSSYYDDSLFDNMRE
|
|
|
|---|
| BDBM34408 |
|---|
| n/a |
|---|
| Name | BDBM34408 |
|---|
| Synonyms: | 4-amino-3-(4-methylphenyl)-5-[(4-methyl-1-piperazinyl)carbonyl]-1,3-thiazole-2(3H)-thione | MLS000088252 | SMR000072496 | [4-amino-3-(4-methylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-(4-methylpiperazin-1-yl)methanone | [4-amino-3-(4-methylphenyl)-2-sulfanylidene-5-thiazolyl]-(4-methyl-1-piperazinyl)methanone | [4-amino-3-(p-tolyl)-2-thioxo-4-thiazolin-5-yl]-(4-methylpiperazino)methanone | [4-azanyl-3-(4-methylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-(4-methylpiperazin-1-yl)methanone | cid_889983 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H20N4OS2 |
|---|
| Mol. Mass. | 348.486 |
|---|
| SMILES | CN1CCN(CC1)C(=O)c1sc(=S)n(c1N)-c1ccc(C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
