| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Ligand | BDBM34966 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase |
|---|
| IC50 | 12800±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Name: | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
|---|
| Synonyms: | n/a |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 109731.64 |
|---|
| Organism: | Plasmodium falciparum 3D7 |
|---|
| Description: | gi_12381848 |
|---|
| Residue: | 950 |
|---|
| Sequence: | MEYETSLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSG
GKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQ
LYKPDTKKDLVSCIRDYNEQIKSMIEKYKKIDIVILGMGSDFHIASLFPNVYYNIYMNNY
QNNYIYEDNETIRSLNADNNVNLSLLNEQVYFTTTNNFDVRKRITVSLNLLSNSTSKIFL
LNTADKLNLWKNMLLNFYVNPNYNLYPAFKMIDSSNTTVIACGHKNYSKMLEDLYVQKDE
ALSPISNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTGQ
DFESFFNKIAIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSPESFENFDVYIT
QEERIALGCCGQKGNEKHKQVNVTSQFPNNHTSINIINNIDNGCESPMLTDSPKRYPCSS
SYSSTSGTAVCPYSSQHDVKPSNNGCPYLSSQANTSDSSGCPYISYHTNKSGHLGCPYTI
TRMLYLALPPHVFVSTLQNYKKYCLNKNRINKILLEKPFGKDLESFKILSKQILETFPEK
NIYRIDHYLGKDMVSGLLKLKFTNIFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYG
IIRDVMQNHMLQLLALITMEHPTDLNDKSIQNEKIKILKSIASIKLEDTVIGQYVKSNND
DTNNNINSNISENASIDKSKINHSYHDDPHVDPNSITPTFCACVLYINSINWHGVPIILK
AGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQ
LNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHIKP
LSYPFGSSGPQEAYDLVRKYYNYGKNYATTAKFCRKSSYYDDSLFDNMRE
|
|
|
|---|
| BDBM34966 |
|---|
| n/a |
|---|
| Name | BDBM34966 |
|---|
| Synonyms: | 3-(3-keto-1,2-benzothiazol-2-yl)-N,N-dimethyl-benzenesulfonamide | MLS000773738 | N,N-dimethyl-3-(3-oxidanylidene-1,2-benzothiazol-2-yl)benzenesulfonamide | N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | SMR000364449 | cid_5040456 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H14N2O3S2 |
|---|
| Mol. Mass. | 334.413 |
|---|
| SMILES | CN(C)S(=O)(=O)c1cccc(c1)-n1sc2ccccc2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
