| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Ligand | BDBM81108 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase |
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| IC50 | >80000±n/a nM |
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| Citation |  PubChem, PC Dose Response orthogonal kinetic assay utilizing the direct detection of NADPH for uHTS small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Name: | Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase |
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| Synonyms: | n/a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 109731.64 |
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| Organism: | Plasmodium falciparum 3D7 |
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| Description: | gi_12381848 |
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| Residue: | 950 |
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| Sequence: | MEYETSLKCLDEIRCVNNVKYMETEDLTDFNKKSAYYICKEIYEKQLSNENGYVVIGLSG
GKTPIDVYKNMCAIKDIKIDKNKLIFFIIDERYKNDDHKFSNYNNIKFLFDELNINKETQ
LYKPDTKKDLVSCIRDYNEQIKSMIEKYKKIDIVILGMGSDFHIASLFPNVYYNIYMNNY
QNNYIYEDNETIRSLNADNNVNLSLLNEQVYFTTTNNFDVRKRITVSLNLLSNSTSKIFL
LNTADKLNLWKNMLLNFYVNPNYNLYPAFKMIDSSNTTVIACGHKNYSKMLEDLYVQKDE
ALSPISNNNVENKNELLTIVIFGCSGDLAKKKIYPALFKLFCNNLLPKNIIIIGFARTGQ
DFESFFNKIAIYLKISLNSYKNLSVFEKAERLNSFKSKCRYFIGNYLSPESFENFDVYIT
QEERIALGCCGQKGNEKHKQVNVTSQFPNNHTSINIINNIDNGCESPMLTDSPKRYPCSS
SYSSTSGTAVCPYSSQHDVKPSNNGCPYLSSQANTSDSSGCPYISYHTNKSGHLGCPYTI
TRMLYLALPPHVFVSTLQNYKKYCLNKNRINKILLEKPFGKDLESFKILSKQILETFPEK
NIYRIDHYLGKDMVSGLLKLKFTNIFLLSLMNRHFIKCIKITLKETKGVYGRGQYFDPYG
IIRDVMQNHMLQLLALITMEHPTDLNDKSIQNEKIKILKSIASIKLEDTVIGQYVKSNND
DTNNNINSNISENASIDKSKINHSYHDDPHVDPNSITPTFCACVLYINSINWHGVPIILK
AGKGLNNDICEIKIQFHNIMGSSDESMYNNEFVIILQPVEGIYLKLMIKKMGSEEMEEVQ
LNLSLNENNNKAYVPEAYETLLSECYKGYKRKFISDEELYESWRIFTPLLNELQEKHIKP
LSYPFGSSGPQEAYDLVRKYYNYGKNYATTAKFCRKSSYYDDSLFDNMRE
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|
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| BDBM81108 |
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| n/a |
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| Name | BDBM81108 |
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| Synonyms: | Biphenyl-4-yl-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanethione | MLS000559855 | SMR000438326 | [4-(2-hydroxyethyl)-1-piperazinyl]-(4-phenylphenyl)methanethione | [4-(2-hydroxyethyl)piperazin-1-yl]-(4-phenylphenyl)methanethione | [4-(2-hydroxyethyl)piperazino]-(4-phenylphenyl)methanethione | cid_848267 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N2OS |
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| Mol. Mass. | 326.456 |
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| SMILES | OCCN1CCN(CC1)C(=S)c1ccc(cc1)-c1ccccc1 |
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| Structure | 
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