| Reaction Details |
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 | Report a problem with these data |
| Target | Endoribonuclease toxin MazF |
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| Ligand | BDBM83487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay |
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| EC50 | 18000±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoribonuclease toxin MazF |
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| Name: | Endoribonuclease toxin MazF |
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| Synonyms: | MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12100.43 |
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| Organism: | Escherichia coli str. K-12 substr. MG1655 |
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| Description: | gi_16130689 |
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| Residue: | 111 |
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| Sequence: | MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPF
EVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
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| BDBM83487 |
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| n/a |
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| Name | BDBM83487 |
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| Synonyms: | 2-[[2-keto-2-(2-thienyl)ethyl]thio]-4,6-dimethyl-nicotinonitrile | 4,6-dimethyl-2-(2-oxidanylidene-2-thiophen-2-yl-ethyl)sulfanyl-pyridine-3-carbonitrile | 4,6-dimethyl-2-(2-oxo-2-thiophen-2-ylethyl)sulfanylpyridine-3-carbonitrile | 4,6-dimethyl-2-[(2-oxo-2-thiophen-2-ylethyl)thio]-3-pyridinecarbonitrile | MLS000105860 | SMR000102835 | cid_685878 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H12N2OS2 |
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| Mol. Mass. | 288.388 |
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| SMILES | Cc1cc(C)c(C#N)c(SCC(=O)c2cccs2)n1 |
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| Structure | 
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