| Reaction Details |
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 | Report a problem with these data |
| Target | Endoribonuclease toxin MazF |
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| Ligand | BDBM83721 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay |
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| EC50 | 1140±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoribonuclease toxin MazF |
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| Name: | Endoribonuclease toxin MazF |
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| Synonyms: | MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12100.43 |
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| Organism: | Escherichia coli str. K-12 substr. MG1655 |
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| Description: | gi_16130689 |
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| Residue: | 111 |
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| Sequence: | MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPF
EVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
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| BDBM83721 |
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| n/a |
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| Name | BDBM83721 |
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| Synonyms: | 6,7-dichloro-2-hydroxy-1,1-diketo-3-(2-keto-2-methoxy-ethyl)-4H-1,2,4-benzothiadiazine-3-carboxylic acid methyl ester | 6,7-dichloro-2-hydroxy-3-(2-methoxy-2-oxoethyl)-1,1-dioxo-4H-1,2,4-benzothiadiazine-3-carboxylic acid methyl ester | MLS002920772 | SMR001798358 | cid_294721 | methyl 6,7-bis(chloranyl)-3-(2-methoxy-2-oxidanylidene-ethyl)-2-oxidanyl-1,1-bis(oxidanylidene)-4H-1,2,4-benzothiadiazine-3-carboxylate | methyl 6,7-dichloro-2-hydroxy-3-(2-methoxy-2-oxoethyl)-1,1-dioxo-4H-1,2,4-benzothiadiazine-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12Cl2N2O7S |
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| Mol. Mass. | 399.204 |
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| SMILES | COC(=O)CC1(Nc2cc(Cl)c(Cl)cc2S(=O)(=O)N1O)C(=O)OC |
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| Structure | 
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