| Reaction Details |
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 | Report a problem with these data |
| Target | Endoribonuclease toxin MazF |
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| Ligand | BDBM52488 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen |
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| EC50 | 48900±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoribonuclease toxin MazF |
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| Name: | Endoribonuclease toxin MazF |
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| Synonyms: | MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 12100.43 |
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| Organism: | Escherichia coli str. K-12 substr. MG1655 |
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| Description: | gi_16130689 |
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| Residue: | 111 |
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| Sequence: | MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPF
EVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
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| BDBM52488 |
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| n/a |
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| Name | BDBM52488 |
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| Synonyms: | (E)-2-cyano-3-[5-[4-(difluoromethylsulfanyl)phenyl]furan-2-yl]-N-(5-methyl-2-phenylpyrazol-3-yl)prop-2-enamide | (E)-2-cyano-3-[5-[4-(difluoromethylthio)phenyl]-2-furanyl]-N-(5-methyl-2-phenyl-3-pyrazolyl)-2-propenamide | (E)-2-cyano-3-[5-[4-(difluoromethylthio)phenyl]-2-furyl]-N-(5-methyl-2-phenyl-pyrazol-3-yl)acrylamide | (E)-3-[5-[4-[bis(fluoranyl)methylsulfanyl]phenyl]furan-2-yl]-2-cyano-N-(5-methyl-2-phenyl-pyrazol-3-yl)prop-2-enamide | MLS000391890 | SMR000260923 | cid_6011596 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H18F2N4O2S |
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| Mol. Mass. | 476.498 |
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| SMILES | Cc1cc(NC(=O)C(=C\c2ccc(o2)-c2ccc(SC(F)F)cc2)\C#N)n(n1)-c1ccccc1 |
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| Structure | 
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