| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptotic protease-activating factor 1 |
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| Ligand | BDBM41831 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay |
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| IC50 | 4460±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptotic protease-activating factor 1 |
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| Name: | Apoptotic protease-activating factor 1 |
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| Synonyms: | APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 141834.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14727 |
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| Residue: | 1248 |
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| Sequence: | MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
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| BDBM41831 |
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| n/a |
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| Name | BDBM41831 |
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| Synonyms: | Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-m-tolyl-hydrazide | MLS000552764 | N-(3-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide | N-(3-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide | N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide | N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide | SMR000146279 | cid_759945 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14N2O2S |
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| Mol. Mass. | 310.37 |
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| SMILES | CC(=O)N(N=C1Sc2ccccc2C1=O)c1cccc(C)c1 |w:4.3| |
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| Structure | 
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