| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptotic protease-activating factor 1 |
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| Ligand | BDBM34648 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay |
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| IC50 | >100000±0 nM |
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| Citation |  PubChem, PC Dose Response validation of Inhibitors of Apaf-1 using a Fluorescent Interference Counterscreen assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptotic protease-activating factor 1 |
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| Name: | Apoptotic protease-activating factor 1 |
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| Synonyms: | APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 141834.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14727 |
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| Residue: | 1248 |
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| Sequence: | MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
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| BDBM34648 |
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| n/a |
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| Name | BDBM34648 |
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| Synonyms: | (4-chlorodithiazol-5-ylidene)-(4,6-dimethyl-2-pyridyl)amine | 4-chloranyl-N-(4,6-dimethylpyridin-2-yl)-1,2,3-dithiazol-5-imine | 4-chloro-N-(4,6-dimethyl-2-pyridinyl)-5-dithiazolimine | 4-chloro-N-(4,6-dimethylpyridin-2-yl)dithiazol-5-imine | MLS000104333 | SMR000054268 | cid_757789 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H8ClN3S2 |
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| Mol. Mass. | 257.763 |
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| SMILES | Cc1cc(C)nc(c1)N=c1ssnc1Cl |w:8.8| |
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| Structure | 
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