| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Apoptotic protease-activating factor 1 |
|---|
| Ligand | BDBM84008 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format |
|---|
| EC50 | 8230±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Apoptotic protease-activating factor 1 |
|---|
| Name: | Apoptotic protease-activating factor 1 |
|---|
| Synonyms: | APAF1 | APAF_HUMAN | Apoptotic peptidase activating factor 1 | KIAA0413 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 141834.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14727 |
|---|
| Residue: | 1248 |
|---|
| Sequence: | MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMI
LKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP
QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPG
GVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL
ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVN
MKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD
YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN
KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC
MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAV
SENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINK
KNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEV
LCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGS
SDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKS
INVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH
STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTS
SDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT
EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS
SSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKD
FVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDST
LLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIK
WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
|
|
|
|---|
| BDBM84008 |
|---|
| n/a |
|---|
| Name | BDBM84008 |
|---|
| Synonyms: | 2-[[4-[2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]-3-nitro-phenyl]sulfonylamino]benzoic acid | 2-[[4-[2-[(4-methylsulfanylphenyl)methylidene]hydrazinyl]-3-nitrophenyl]sulfonylamino]benzoic acid | 2-[[4-[2-[[4-(methylthio)phenyl]methylidene]hydrazinyl]-3-nitrophenyl]sulfonylamino]benzoic acid | 2-[[4-[N'-[4-(methylthio)benzylidene]hydrazino]-3-nitro-phenyl]sulfonylamino]benzoic acid | MLS002245633 | SMR001309277 | cid_3292268 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H18N4O6S2 |
|---|
| Mol. Mass. | 486.521 |
|---|
| SMILES | CSc1ccc(CN=Nc2ccc(cc2[N+]([O-])=O)S(=O)(=O)Nc2ccccc2C(O)=O)cc1 |w:8.8| |
|---|
| Structure | 
|
|---|
Search and Browse
