| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-9 |
|---|
| Ligand | BDBM43224 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay |
|---|
| IC50 | 51.9±n/a nM |
|---|
| Citation |  PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay(2011)[AID] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-9 |
|---|
| Name: | Caspase-9 |
|---|
| Synonyms: | Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 46277.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 416 |
|---|
| Sequence: | MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
|
|
|
|---|
| BDBM43224 |
|---|
| n/a |
|---|
| Name | BDBM43224 |
|---|
| Synonyms: | 1-ethyl-6-methyl-3-[(E)-2-phenylethenyl]pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1-ethyl-6-methyl-3-[(E)-styryl]pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | MLS000717146 | SMR000278513 | US9073941, 609 | cid_5756371 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H15N5O2 |
|---|
| Mol. Mass. | 309.3226 |
|---|
| SMILES | CCn1nc(\C=C\c2ccccc2)nc2c1nc(=O)n(C)c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
