| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-9 |
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| Ligand | BDBM83940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay |
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| IC50 | 7380±n/a nM |
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| Citation |  PubChem, PC Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-9 |
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| Name: | Caspase-9 |
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| Synonyms: | Apoptotic protease-activating factor 1/Caspase-3/Caspase-9/Cytochrome c | Apoptotic protease-activating factor 3 | CASP-9 | CASP9 | CASP9_HUMAN | Caspase 9 | ICE-like apoptotic protease 6 | MCH6 | caspase-9 isoform alpha preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 46277.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 416 |
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| Sequence: | MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
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| BDBM83940 |
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| n/a |
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| Name | BDBM83940 |
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| Synonyms: | 4-O-[5-bromo-2-(2-methoxyethyl)-3-(4-methoxyphenyl)-7-methyl-6,8-dioxoisoquinolin-7-yl] 1-O-methyl butanedioate | CMLD004052 | MLS001045840 | O4-[5-bromanyl-2-(2-methoxyethyl)-3-(4-methoxyphenyl)-7-methyl-6,8-bis(oxidanylidene)isoquinolin-7-yl] O1-methyl butanedioate | SMR000452737 | butanedioic acid O4-[5-bromo-2-(2-methoxyethyl)-3-(4-methoxyphenyl)-7-methyl-6,8-dioxo-7-isoquinolinyl] ester O1-methyl ester | cid_16759695 | succinic acid O4-[5-bromo-6,8-diketo-2-(2-methoxyethyl)-3-(4-methoxyphenyl)-7-methyl-7-isoquinolyl] ester O1-methyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26BrNO8 |
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| Mol. Mass. | 548.38 |
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| SMILES | COCCN1C=C2C(=O)C(C)(OC(=O)CCC(=O)OC)C(=O)C(Br)=C2C=C1c1ccc(OC)cc1 |c:23,26,t:5| |
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| Structure | 
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