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TargetToll-like receptor 7
LigandBDBM273910
Substrate/Competitorn/a
Meas. Tech.TLR7/8/9 Inhibition Reporter Assay
Temperature298.15±n/a K
IC50 0.200±n/a nM
Commentsextracted
Citation Dyckman AJDodd DSMacor JEMussari CPPasunoori LKumar SRSherwood TCSistla RK [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds US Patent  US10071079 Publication Date 9/11/2018
More Info.:Get all data from this article,  Assay Method
 
Toll-like receptor 7
Name:TLR7 and TLR8
Synonyms:ORF Names:UNQ248/PRO285 | TLR7 | Toll-like receptor 7 (TLR7)
Type:Enzyme
Mol. Mass.:120945.35
Organism:Homo sapiens (Human)
Description:Q9NYK1
Residue:1049
Sequence:
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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  Blast E-value cutoff:
BDBM273910
n/a
NameBDBM273910
Synonyms:US10071079, Example 696
TypeSmall organic molecule
Emp. Form.C29H36N6O
Mol. Mass.484.6357
SMILESCC(C)c1c([nH]c2ccc(cc12)C1CCN(CC1)C(=O)CN(C)C)-c1cc(C2CC2)c2ncnn2c1
Structure
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