| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM84602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| Ki | 5.8e+3±n/a nM |
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| Citation |  Calò, S; Tondi, D; Ferrari, S; Venturelli, A; Ghelli, S; Costi, MP Constrained dansyl derivatives reveal bacterial specificity of highly conserved thymidylate synthases. Chembiochem9:779-90 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
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| Type: | Enzyme |
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| Mol. Mass.: | 36576.54 |
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| Organism: | Lactobacillus casei |
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| Description: | n/a |
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| Residue: | 316 |
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| Sequence: | MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
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| BDBM84602 |
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| n/a |
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| Name | BDBM84602 |
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| Synonyms: | Dansyl derivative, 6L |
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| Type | Small organic molecule |
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| Emp. Form. | C31H36N2O8S2 |
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| Mol. Mass. | 628.756 |
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| SMILES | CN(C)c1cccc2c(cccc12)S(=O)(=O)Oc1ccc(C[C@H](NS(=O)(=O)CC23CCC(C(=O)C2)C3(C)C)C(O)=O)cc1 |r,TLB:33:32:29.30:35| |
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| Structure | 
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