| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 [60-463] |
|---|
| Ligand | BDBM274222 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET In-Vitro Binding Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | <11.0±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 2 [60-463] |
|---|
| Name: | Bromodomain-containing protein 2 [60-463] |
|---|
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 | KIAA9001 | RING3 |
|---|
| Type: | Enzyme Catalytic Domain (aa 60-463) |
|---|
| Mol. Mass.: | 45228.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25440[60-463] |
|---|
| Residue: | 404 |
|---|
| Sequence: | NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ
PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS
MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN
IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP
ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE
LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR
LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPL
|
|
|
|---|
| BDBM274222 |
|---|
| n/a |
|---|
| Name | BDBM274222 |
|---|
| Synonyms: | 1-(1-acetylazetidin-3-yl)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one | US9550796, Example 17 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H27ClN6O2 |
|---|
| Mol. Mass. | 515.006 |
|---|
| SMILES | CC(=O)N1CC(C1)n1cc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
