Reaction Details |
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Target | Bromodomain-containing protein 2 [60-463] |
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Ligand | BDBM274294 |
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Substrate/Competitor | n/a |
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Meas. Tech. | TR-FRET In-Vitro Binding Assay |
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pH | 7.5±n/a |
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IC50 | 34.0±n/a nM |
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Comments | extracted |
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Citation | Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 2 [60-463] |
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Name: | Bromodomain-containing protein 2 [60-463] |
Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain-containing protein 2 | KIAA9001 | RING3 |
Type: | Enzyme Catalytic Domain (aa 60-463) |
Mol. Mass.: | 45228.55 |
Organism: | Homo sapiens (Human) |
Description: | P25440[60-463] |
Residue: | 404 |
Sequence: | NPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQ
PMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVAS
MPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLN
IPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSP
ASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKE
LLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVR
LMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPL
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BDBM274294 |
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n/a |
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Name | BDBM274294 |
Synonyms: | Tert-butyl (6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)-1-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-3-yl)carbamate | US9550796, Example 95 |
Type | Small organic molecule |
Emp. Form. | C25H26ClN7O3 |
Mol. Mass. | 507.972 |
SMILES | Cc1cc(nc2n(C)nnc12)N1C(c2c(C1=O)c(NC(=O)OC(C)(C)C)cn2C)c1ccc(Cl)cc1 |
Structure |
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