| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 4 [44-477] |
|---|
| Ligand | BDBM274310 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | TR-FRET In-Vitro Binding Assay |
|---|
| pH | 7.5±n/a |
|---|
| IC50 | <11.0±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 4 [44-477] |
|---|
| Name: | Bromodomain-containing protein 4 [44-477] |
|---|
| Synonyms: | BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 | HUNK1 |
|---|
| Type: | Enzyme Catalytic Domain (aa 44-477) |
|---|
| Mol. Mass.: | 48692.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O60885[44-477] |
|---|
| Residue: | 434 |
|---|
| Sequence: | NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKT
PMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINE
LPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPH
PFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVK
TKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPA
PEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTI
KSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEE
PVVAVSSPAVPPPT
|
|
|
|---|
| BDBM274310 |
|---|
| n/a |
|---|
| Name | BDBM274310 |
|---|
| Synonyms: | 1-(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-1-methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4-b]pyrrol-3-yl)-3-methylurea | US9550796, Example 111 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19ClF2N8O2 |
|---|
| Mol. Mass. | 500.888 |
|---|
| SMILES | CNC(=O)Nc1cn(C)c2C(N(C(=O)c12)c1cc(C)c2nnc(C(F)F)n2n1)c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
