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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Bromodomain-containing protein 3 | ||
| Ligand | BDBM274319 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | TR-FRET In-Vitro Binding Assay | ||
| pH | 7.5±n/a | ||
| IC50 | <11.0±n/a nM | ||
| Comments | extracted | ||
| Citation |  Rueger, H; Blank, J; Bordas, V; Cotesta, S; Bold, G; Guagnano, V; Vaupel, A Pyrrolopyrrolone derivatives and their use as BET inhibitors US Patent US9550796 Publication Date 1/24/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Bromodomain-containing protein 3 | |||
| Name: | Bromodomain-containing protein 3 | ||
| Synonyms: | BRD3 | BRD3_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 3 | Bromodomain-containing protein 3 (BRD3) | KIAA0043 | RING3-like protein | RING3L | ||
| Type: | Protein | ||
| Mol. Mass.: | 79571.81 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15059 | ||
| Residue: | 726 | ||
| Sequence: |
| ||
| BDBM274319 | |||
| n/a | |||
| Name | BDBM274319 | ||
| Synonyms: | 6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-di methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(2-methoxypyridin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one | US9550796, Example 120 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H27ClN6O2 | ||
| Mol. Mass. | 539.027 | ||
| SMILES | COc1ncccc1-c1c(C2CC2)c2C(=O)N(C(c2n1C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1 |(5.51,-2.51,;4.74,-1.18,;5.51,.15,;7.05,.15,;7.82,1.49,;7.05,2.82,;5.51,2.82,;4.74,1.49,;3.2,1.49,;2.3,2.73,;2.7,4.22,;3.79,5.31,;2.3,5.71,;.83,2.26,;-.63,2.73,;-1.4,4.07,;-1.54,1.49,;-.63,.24,;.83,.72,;2.3,.24,;3.07,-1.09,;-1.03,-1.25,;.06,-2.33,;-.34,-3.82,;-1.83,-4.22,;-2.23,-5.71,;-2.92,-3.13,;-2.52,-1.64,;-3.08,1.49,;-3.85,2.82,;-5.39,2.82,;-6.16,4.15,;-6.16,1.49,;-7.66,1.17,;-7.82,-.36,;-6.42,-.99,;-6.02,-2.48,;-5.39,.15,;-3.85,.15,)| | ||
| Structure | 
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