Reaction Details |
| Report a problem with these data |
Target | Queuine tRNA-ribosyltransferase |
---|
Ligand | BDBM84652 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Assay |
---|
pH | 7.3±0 |
---|
Ki | 3.1e+4± 1.0e+4 nM |
---|
Citation | Ritschel, T; Hoertner, S; Heine, A; Diederich, F; Klebe, G Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT. Chembiochem10:716-27 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Queuine tRNA-ribosyltransferase |
---|
Name: | Queuine tRNA-ribosyltransferase |
Synonyms: | TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt |
Type: | Protein |
Mol. Mass.: | 42844.19 |
Organism: | Zymomonas mobilis |
Description: | P28720 |
Residue: | 386 |
Sequence: | MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEE
GVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAK
RSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEM
FRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPI
NIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQK
IRDSISEGRFSQFAQDFRARYFARNS
|
|
|
BDBM84652 |
---|
n/a |
---|
Name | BDBM84652 |
Synonyms: | Quinazolinone scaffold, 1 |
Type | Small organic molecule |
Emp. Form. | C10H12N4O |
Mol. Mass. | 204.2285 |
SMILES | CN(C)c1ccc2c(c1)nc(N)[nH]c2=O |
Structure |
|