| Reaction Details |
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 | Report a problem with these data |
| Target | Queuine tRNA-ribosyltransferase |
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| Ligand | BDBM84661 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| pH | 7.3±0 |
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| Ki | 10±3 nM |
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| Citation |  Ritschel, T; Hoertner, S; Heine, A; Diederich, F; Klebe, G Crystal structure analysis and in silico pKa calculations suggest strong pKa shifts of ligands as driving force for high-affinity binding to TGT. Chembiochem10:716-27 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Queuine tRNA-ribosyltransferase |
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| Name: | Queuine tRNA-ribosyltransferase |
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| Synonyms: | TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt |
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| Type: | Protein |
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| Mol. Mass.: | 42844.19 |
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| Organism: | Zymomonas mobilis |
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| Description: | P28720 |
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| Residue: | 386 |
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| Sequence: | MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVR
ATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEE
GVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAK
RSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEM
FRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPI
NIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQK
IRDSISEGRFSQFAQDFRARYFARNS
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| BDBM84661 |
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| n/a |
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| Name | BDBM84661 |
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| Synonyms: | lin-benzoguanine scaffold, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N6O |
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| Mol. Mass. | 320.3485 |
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| SMILES | Nc1nc2cc3nc(NCCc4ccccc4)[nH]c3cc2c(=O)[nH]1 |
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| Structure | 
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