| Reaction Details |
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 | Report a problem with these data |
| Target | Trans-sialidase |
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| Ligand | BDBM50174833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.6±0 |
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| Temperature | 308.15±0 K |
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| Ki | 3.7e+3±n/a nM |
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| IC50 | 2.5e+3±n/a nM |
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| Citation |  Kim, JH; Ryu, HW; Shim, JH; Park, KH; Withers, SG Development of new and selective Trypanosoma cruzi trans-sialidase inhibitors from sulfonamide chalcones and their derivatives. Chembiochem10:2475-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Trans-sialidase |
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| Name: | Trans-sialidase |
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| Synonyms: | n/a |
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| Type: | n/a |
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| Mol. Mass.: | 70598.62 |
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| Organism: | Trypanosoma cruzi |
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| Description: | Q26966 |
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| Residue: | 642 |
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| Sequence: | MLAPGSSRVELFKRQSSKVPFEKDGKVTERVVHSFRLPALVNVDGVMVAIADARYETSND
NSLIDTVAKYSVDDGETWETQIAIKNSRASSVSRVVDPTVIVKGNKLYVLVGSYNSSRSY
WTSHGDARDWDILLAVGEVTKSTAGGKITASIKWGSPVSLKEFFPAEMEGMHTNQFLGGA
GVAIVASNGNLVYPVQVTNKKKQVFSKIFYSEDEGKTWKFGKGRSAFGCSEPVALEWEGK
LIINTRVDYRRRLVYESSDMGNSWLEAVGTLSRVWGPSPKSNQPGSQSSFTAVTIEGMRV
MLFTHPLNFKGRWLRDRLNLWLTDNQRIYNVGQVSIGDENSAYSSVLYKDDKLYCLHEIN
SNEVYSLVFARLVGELRIIKSVLQSWKNWDSHLSSICTPADPAASSSERGCGPAVTTVGL
VGFLSHSATKTEWEDAYRCVNASTANAERVPNGLKFAGVGGGALWPVSQQGQNQRYRFAN
HAFTVVASVTIHEVPSVASPLLGASLDSSGGKKLLGLSYDERHQWQPIYGSTPVTPTGSW
EMGKRYHVVLTMANKIGSEYIDGEPLEGSGQTVVPDERTPDISHFYVGGYKRSDMPTISH
VTVNNVLLYNRQLNAEEIRTLFLSQDLIGTEAHMDSSSDTSA
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| BDBM50174833 |
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| n/a |
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| Name | BDBM50174833 |
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| Synonyms: | CHEMBL199442 | N-(3-(3-(3,4-dihydroxyphenyl)acryloyl)phenyl)-4-methylbenzenesulfonamide | Sulfonamide chalcone, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19NO5S |
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| Mol. Mass. | 409.455 |
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| SMILES | Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C(=O)\C=C\c1ccc(O)c(O)c1 |
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| Structure | 
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