Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50000074 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_226551 |
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Ki | 0.840000±n/a nM |
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Citation | de Costa, BR; Radesca, L; Di Paolo, L; Bowen, WD Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. J Med Chem35:38-47 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50000074 |
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n/a |
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Name | BDBM50000074 |
Synonyms: | CHEMBL142596 | [2-(3-Chloro-phenyl)-ethyl]-methyl-(2-pyrrolidin-1-yl-ethyl)-amine |
Type | Small organic molecule |
Emp. Form. | C15H23ClN2 |
Mol. Mass. | 266.81 |
SMILES | CN(CCN1CCCC1)CCc1cccc(Cl)c1 |
Structure |
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