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TargetThromboxane-A synthase
LigandBDBM50000306
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209923 (CHEMBL813714)
IC50 540±n/a nM
Citation Martinez, GR; Walker, KA; Hirschfeld, DR; Bruno, JJ; Yang, DS; Maloney, PJ 3,4-Dihydroquinolin-2(1H)-ones as combined inhibitors of thromboxane A2 synthase and cAMP phosphodiesterase. J Med Chem35:620-8 (1992) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thromboxane-A synthase
Name:Thromboxane-A synthase
Synonyms:CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase
Type:Enzyme
Mol. Mass.:60524.67
Organism:Homo sapiens (Human)
Description:P24557
Residue:533
Sequence:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
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  Blast E-value cutoff:
BDBM50000306
n/a
NameBDBM50000306
Synonyms:6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one | 6-Pyridin-3-yl-3,4-dihydro-1H-quinolin-2-one; HCL | 6-Pyridin-3-yl-3,4-dihydroquinolin-2(1H)-on | CHEMBL62811
TypeSmall organic molecule
Emp. Form.C14H12N2O
Mol. Mass.224.2579
SMILESO=C1CCc2cc(ccc2N1)-c1cccnc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: