| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane prolyl 4-hydroxylase |
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| Ligand | BDBM26114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_157453 |
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| IC50 | 5500±n/a nM |
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| Citation |  Tucker, H; Thomas, DF Novel inhibitors of prolyl 4-hydroxylase. 2. 5-Amide substituted pyridine-2-carboxylic acids. J Med Chem35:804-7 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane prolyl 4-hydroxylase |
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| Name: | Transmembrane prolyl 4-hydroxylase |
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| Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56654.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXG6 |
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| Residue: | 502 |
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| Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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| BDBM26114 |
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| n/a |
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| Name | BDBM26114 |
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| Synonyms: | CHEMBL88972 | pyridine carboxylate, 6b | pyridine-2,5-dicarboxylic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C7H5NO4 |
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| Mol. Mass. | 167.1189 |
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| SMILES | OC(=O)c1ccc(nc1)C(O)=O |
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| Structure | 
|
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