| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain testis-specific protein |
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| Ligand | BDBM25121 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1666425 |
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| IC50 | 1400±n/a nM |
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| Citation |  Ayoub, AM; Hawk, LML; Herzig, RJ; Jiang, J; Wisniewski, AJ; Gee, CT; Zhao, P; Zhu, JY; Berndt, N; Offei-Addo, NK; Scott, TG; Qi, J; Bradner, JE; Ward, TR; Schönbrunn, E; Georg, GI; Pomerantz, WCK BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. J Med Chem60:4805-4817 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain testis-specific protein |
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| Name: | Bromodomain testis-specific protein |
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| Synonyms: | BRDT | BRDT_HUMAN | Bromodomain and extra-terminal motif (BET) | CT9 | Cancer/testis antigen 9 | RING3-like protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 107982.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502985 |
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| Residue: | 947 |
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| Sequence: | MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVK
LQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQ
ALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSV
FPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSV
ALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVD
VNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVT
MARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERV
KRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRL
KEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSR
EPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQ
ELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSS
DSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTL
VHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGD
SDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKA
RTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQD
KSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
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| BDBM25121 |
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| n/a |
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| Name | BDBM25121 |
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| Synonyms: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | BI 2536 | CHEMBL513909 | US10450297, Example 300 | US8598172, 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H39N7O3 |
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| Mol. Mass. | 521.6544 |
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| SMILES | CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O |r| |
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| Structure | 
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