Ki Summary

Reaction Details

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Target

Platelet-activating factor receptor

Ligand

BDBM50000713

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_155155

23500±n/a nM

Citation

Guinn, DE; Summers, JB; Heyman, HR; Conway, RG; Rhein, DA; Albert, DH; Magoc, T; Carter, GW Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists. J Med Chem35:2055-61 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Platelet-activating factor receptor

Name:

Platelet-activating factor receptor

Synonyms:

PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor

Type:

Protein

Mol. Mass.:

39005.63

Organism:

Cavia porcellus

Description:

n/a

Residue:

342

Sequence:

MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLT
VADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVK
YPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKG
SKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAV
FVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKF
RKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN

BDBM50000713

n/a

Name

BDBM50000713

Synonyms:

2-[5-{4-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-2,6-dihydroxy-phenyl}-4-(1-hydroxy-1-methyl-ethyl)-3,6-dihydro-2H-pyridin-1-yl]-N-methyl-acetamide | CHEMBL65715

Type

Small organic molecule

Emp. Form.

C28H37FN2O4

Mol. Mass.

484.6028

SMILES

CNC(=O)CN1CCC(=C(C1)c1c(O)cc(cc1O)C(C)CCCc1ccc(F)cc1)C(C)(C)O |c:8,(7.36,1.79,;6.01,1.02,;6.03,-.52,;7.36,-1.29,;4.7,-1.32,;4.7,-2.86,;3.38,-3.63,;3.38,-5.17,;4.7,-5.91,;6.03,-5.17,;6.03,-3.63,;7.36,-5.91,;7.36,-7.45,;6.03,-8.22,;8.67,-8.21,;10.01,-7.45,;9.99,-5.91,;8.67,-5.17,;8.67,-3.63,;11.34,-8.22,;11.34,-9.76,;12.67,-7.44,;14,-8.21,;15.34,-7.44,;16.66,-8.21,;16.66,-9.75,;18.01,-10.5,;19.35,-9.73,;20.67,-10.5,;19.33,-8.19,;18,-7.42,;3.35,-6.68,;3.34,-8.21,;2.03,-5.88,;2.02,-7.44,)|

Structure