| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 11B1, mitochondrial |
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| Ligand | BDBM50239790 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667115 (CHEMBL4016911) |
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| IC50 | 4000±n/a nM |
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| Citation |  Emmerich, J; van Koppen, CJ; Burkhart, JL; Hu, Q; Siebenbürger, L; Boerger, C; Scheuer, C; Laschke, MW; Menger, MD; Hartmann, RW Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease. J Med Chem60:5086-5098 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 11B1, mitochondrial |
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| Name: | Cytochrome P450 11B1, mitochondrial |
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| Synonyms: | C11B1_RAT | Cyp11b-1 | Cyp11b1 | Cytochrome P450 11B | Cytochrome P450 11B1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57478.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1475489 |
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| Residue: | 499 |
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| Sequence: | MALRVTADVWLARPWQCLHRTRALGTTAKVAPKTLKPFEAIPQYSRNKWLKMIQILREQG
QENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPHRMPLEPWVAHR
ELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAIQSFVPFVDVVARDFVENLKKRMLENV
HGSMSINIQSNMFNYTMEASHFVISGERLGLTGHDLKPESVTFTHALHSMFKSTTQLMFL
PKSLTRWTSTRVWKEHFDSWDIISEYVTKCIKNVYRELAEGRQQSWSVISEMVAQSTLSM
DAIHANSMELIAGSVDTTAISLVMTLFELARNPDVQQALRQESLAAEASIVANPQKAMSD
LPLLRAALKETLRLYPVGSFVERIVHSDLVLQNYHVPAGTFVIIYLYSMGRNPAVFPRPE
RYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDMQMV
FRFLLMPSSSPFLTFRPVS
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| BDBM50239790 |
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| n/a |
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| Name | BDBM50239790 |
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| Synonyms: | CHEMBL4079276 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N2O |
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| Mol. Mass. | 250.2952 |
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| SMILES | Cc1cncc(Cc2cc(no2)-c2ccccc2)c1 |
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| Structure | 
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