| Reaction Details |
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 | Report a problem with these data |
| Target | Programmed cell death 1 ligand 1 |
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| Ligand | BDBM50239947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667595 (CHEMBL4017391) |
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| IC50 | 18±n/a nM |
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| Citation |  Guzik, K; Zak, KM; Grudnik, P; Magiera, K; Musielak, B; Törner, R; Skalniak, L; Dömling, A; Dubin, G; Holak, TA Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem60:5857-5867 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Programmed cell death 1 ligand 1 |
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| Name: | Programmed cell death 1 ligand 1 |
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| Synonyms: | B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33278.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109807 |
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| Residue: | 290 |
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| Sequence: | MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
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| BDBM50239947 |
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| n/a |
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| Name | BDBM50239947 |
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| Synonyms: | CHEMBL4089730 | US20230303494, Compound BMS202 | US20240043392, Compound BMS-202 | US9872852, Example 202 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H29N3O3 |
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| Mol. Mass. | 419.5161 |
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| SMILES | COc1nc(OCc2cccc(c2C)-c2ccccc2)ccc1CNCCNC(C)=O |
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| Structure | 
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