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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Protein kinase C theta type | ||
| Ligand | BDBM50240301 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1668070 (CHEMBL4017958) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Katoh, T; Tomata, Y; Setoh, M; Sasaki, S; Takai, T; Yoshitomi, Y; Yukawa, T; Nakagawa, H; Fukumoto, S; Tsukamoto, T; Nakada, Y Practical application of 3-substituted-2,6-difluoropyridines in drug discovery: Facile synthesis of novel protein kinase C theta inhibitors. Bioorg Med Chem Lett27:2497-2501 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Protein kinase C theta type | |||
| Name: | Protein kinase C theta type | ||
| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 81878.04 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). | ||
| Residue: | 706 | ||
| Sequence: |
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| BDBM50240301 | |||
| n/a | |||
| Name | BDBM50240301 | ||
| Synonyms: | CHEMBL4074629 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H17ClN6O | ||
| Mol. Mass. | 344.799 | ||
| SMILES | Clc1ccc(nc1-n1c2cccnc2[nH]c1=O)N1CCCNCC1 |(7.24,-4.14,;8.58,-4.91,;9.91,-4.14,;11.24,-4.9,;11.25,-6.45,;9.91,-7.22,;8.57,-6.45,;7.24,-7.22,;7.09,-8.75,;8.11,-9.89,;7.63,-11.34,;6.12,-11.66,;5.1,-10.52,;5.58,-9.06,;4.81,-7.74,;5.84,-6.59,;5.53,-5.09,;12.58,-7.22,;12.46,-8.76,;13.6,-9.8,;15.12,-9.56,;15.89,-8.23,;15.32,-6.8,;13.84,-6.35,)| | ||
| Structure | 
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