| Reaction Details |
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 | Report a problem with these data |
| Target | Meprin A subunit beta |
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| Ligand | BDBM13105 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1668162 (CHEMBL4018050) |
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| IC50 | 34950±n/a nM |
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| Citation |  Ramsbeck, D; Hamann, A; Schlenzig, D; Schilling, S; Buchholz, M First insight into structure-activity relationships of selective meprin? inhibitors. Bioorg Med Chem Lett27:2428-2431 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Meprin A subunit beta |
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| Name: | Meprin A subunit beta |
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| Synonyms: | 3.4.24.63 | Endopeptidase-2 | MEP1B | MEP1B_HUMAN | Meprin A subunit beta | Meprin B | N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta | PABA peptide hydrolase | PPH beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79560.71 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117484 |
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| Residue: | 701 |
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| Sequence: | MDLWNLSWFLFLDALLVISGLATPENFDVDGGMDQDIFDINEGLGLDLFEGDIRLDRAQI
RNSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAGETNYISVFK
GSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRI
LSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQNGTEPTIVTRISDFEDVIGQRMD
FSDSDLLKLNQLYNCSSSLSFMDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHS
NMGQCQGSGFFMHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIR
EYSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGASLGGLSIDDI
NLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAFQIYLNLAHVTNAGIYFHLI
SGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVG
TVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTP
APSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDTIVIAVSST
VAVFALMLIITLVSVYCTRKKYRERMSSNRPNLTPQNQHAF
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| BDBM13105 |
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| n/a |
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| Name | BDBM13105 |
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| Synonyms: | CGS 27023A Analog 33 | N-hydroxy-2-[(4-methoxybenzene)[(4-methoxyphenyl)methyl]sulfonamido]acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N2O6S |
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| Mol. Mass. | 380.415 |
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| SMILES | COc1ccc(CN(CC(=O)NO)S(=O)(=O)c2ccc(OC)cc2)cc1 |
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| Structure | 
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