Reaction Details |
| Report a problem with these data |
Target | Muscarinic acetylcholine receptor M5 |
---|
Ligand | BDBM50240546 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1668366 (CHEMBL4018254) |
---|
IC50 | <1500±n/a nM |
---|
Citation | Bender, AM; Weiner, RL; Luscombe, VB; Cho, HP; Niswender, CM; Engers, DW; Bridges, TM; Conn, PJ; Lindsley, CW Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. Bioorg Med Chem Lett27:2479-2483 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Muscarinic acetylcholine receptor M5 |
---|
Name: | Muscarinic acetylcholine receptor M5 |
Synonyms: | ACM5_HUMAN | CHRM5 |
Type: | PROTEIN |
Mol. Mass.: | 60102.35 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1517990 |
Residue: | 532 |
Sequence: | MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
|
|
|
BDBM50240546 |
---|
n/a |
---|
Name | BDBM50240546 |
Synonyms: | CHEMBL4085711 |
Type | Small organic molecule |
Emp. Form. | C27H30N4O2 |
Mol. Mass. | 442.5527 |
SMILES | CCc1ccc(Oc2cc(ncn2)N2CCC(CC2)C(=O)N2CCc3ccccc3C2)cc1 |
Structure |
|