Reaction Details | |||
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Target | Wee1-like protein kinase 2 | ||
Ligand | BDBM3096 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1668980 (CHEMBL4018868) | ||
Kd | 5.0±n/a nM | ||
Citation | Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J Med Chem60:7863-7875 (2017) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase 2 | |||
Name: | Wee1-like protein kinase 2 | ||
Synonyms: | WEE1B | WEE2 | WEE2_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 62923.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_774226 | ||
Residue: | 567 | ||
Sequence: |
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BDBM3096 | |||
n/a | |||
Name | BDBM3096 | ||
Synonyms: | 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6-(2,6-Dichlorophenyl)-2-[4-(2-diethylaminoethoxy)phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, Dihydrochloride | 6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one | CHEMBL49120 | D3RKN_84 | PD166285 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H27Cl2N5O2 | ||
Mol. Mass. | 512.431 | ||
SMILES | CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| | ||
Structure |