| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-8 |
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| Ligand | BDBM50240928 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1669328 (CHEMBL4019216) |
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| IC50 | 76100±n/a nM |
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| Citation |  Qi, Q; Obianyo, O; Du, Y; Fu, H; Li, S; Ye, K Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis. J Med Chem60:7244-7255 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-8 |
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| Name: | Caspase-8 |
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| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 55373.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14790 |
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| Residue: | 479 |
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| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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| BDBM50240928 |
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| n/a |
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| Name | BDBM50240928 |
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| Synonyms: | CHEMBL4067280 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15ClN4O4S |
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| Mol. Mass. | 382.822 |
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| SMILES | Cn1c2nc(S)n(CC(O)COc3ccc(Cl)cc3)c2c(=O)[nH]c1=O |
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| Structure | 
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