| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
|---|
| Ligand | BDBM25762 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_39159 |
|---|
| IC50 | 9000±n/a nM |
|---|
| Citation |  Phillips, GB; Morgan, TK; Lumma, WC; Gomez, RP; Lind, JM; Lis, R; Argentieri, T; Sullivan, ME Synthesis, cardiac electrophysiology, and beta-blocking activity of novel arylpiperazines with potential as class II/III antiarrhythmic agents. J Med Chem35:743-50 (1992) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-1 adrenergic receptor |
|---|
| Name: | Beta-1 adrenergic receptor |
|---|
| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 51338.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08588 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
|
|
|
|---|
| BDBM25762 |
|---|
| n/a |
|---|
| Name | BDBM25762 |
|---|
| Synonyms: | CHEMBL471 | N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide | SOTALOL HYDROCHLORIDE | Sotalol | Sotalol,(+) | Sotalol,(-) | cid_66245 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H20N2O3S |
|---|
| Mol. Mass. | 272.364 |
|---|
| SMILES | CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
