| Reaction Details |
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 | Report a problem with these data |
| Target | DNA repair protein complementing XP-A cells |
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| Ligand | BDBM50241713 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1670186 (CHEMBL4020074) |
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| IC50 | 820±n/a nM |
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| Citation |  Gavande, NS; VanderVere-Carozza, P; Mishra, AK; Vernon, TL; Pawelczak, KS; Turchi, JJ Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction. J Med Chem60:8055-8070 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA repair protein complementing XP-A cells |
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| Name: | DNA repair protein complementing XP-A cells |
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| Synonyms: | DNA repair protein complementing XP-A cells | XPA | XPAC | XPA_HUMAN | Xeroderma pigmentosum group A-complementing protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31368.63 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117406 |
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| Residue: | 273 |
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| Sequence: | MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM
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| BDBM50241713 |
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| n/a |
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| Name | BDBM50241713 |
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| Synonyms: | CHEMBL4065804 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H20Cl2N2O6 |
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| Mol. Mass. | 575.396 |
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| SMILES | CC1=NN(C(=O)\C1=C/c1ccc(o1)-c1ccc(Cl)c(c1)C(=O)OCc1ccccc1)c1ccc(Cl)c(c1)C(O)=O |t:1| |
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| Structure | 
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