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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Vitamin D3 receptor | ||
| Ligand | BDBM50200182 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1670491 (CHEMBL4020379) | ||
| IC50 | 0.160000±n/a nM | ||
| Citation |  Kato, A; Yamao, M; Hashihara, Y; Ishida, H; Itoh, T; Yamamoto, K Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action. J Med Chem60:8394-8406 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Vitamin D3 receptor | |||
| Name: | Vitamin D3 receptor | ||
| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN | ||
| Type: | Protein | ||
| Mol. Mass.: | 48288.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11473 | ||
| Residue: | 427 | ||
| Sequence: |
| ||
| BDBM50200182 | |||
| n/a | |||
| Name | BDBM50200182 | ||
| Synonyms: | (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol | (1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | (5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol | 1,25-DHCC | 1alpha,25(OH)2D3 | 1alpha,25-dihydroxycholecalciferol | 1alpha,25-dihydroxyvitamin D3 | CALCITRIOL | CHEMBL846 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H44O3 | ||
| Mol. Mass. | 416.6365 | ||
| SMILES | C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| | ||
| Structure | 
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